This work involves to synthesis derivatives of 4-Amino phenazone and studies their biological activity. Approach the title synthesis devieatives were prepared by reacting 4-Amino phenazone with Salicylaldehyde to form azo compound. The second step azo compound reacting with various amines to give Schiff bases. The last Schiff bases reacting with maleic and phthalic anhydride. The chemical structures of the synthesized compounds were confirmed on the basis of their spectral data (FTIR, HNMR spectra and CHN analysis).