Objective: The main objective of the study was to find the association between smokeless tobacco use and general and reproductive health problems. Materials and methods: The study population consisted of 800 women from selected villages of Peranankila Panchayat, Udupi district. Four villages of the Panchayat were selected through simple random technique and purposive sampling was used to select the samples. Data were collected by administering background proforma and rating scale for the assessment for health problems. Results: Out of the 800 women surveyed, 90 women were using smokeless tobacco. Majority of the women 30 (33.3%) who used smokeless tobacco reported that they had excessive vomiting during pregnancy followed by severe nausea (31.1%). Majority of the women reported that they had low birth weight babies (8.9% of users and 3.5% of non-users). All the women who used smokeless tobacco had stained teeth. Chi-square and odds ratio was computed to find the association. Low backache was the commonest problem among the women [users (23.3%) and non-users (4.5%)]. There were 70% of women who use smokeless tobacco who had one or more obstetrical problem whereas it is 37.5% among the non-users. Neonatal problems in women who use SLT were 22.2% whereas it is 9.3% among women who did not use SLT. A significant association was found between smokeless tobacco use and obstetrical, neonatal, oral, reproductive health and other problems. No association was found between smokeless tobacco use and gastrointestinal and urinary problems. Conclusion: The International Agency for Research on Cancer (IARC) has found that people who chew both the betel leaf and the areca nut have a higher risk of damaging their gums and having cancers of the mouth, pharynx, esophagus, and stomach. Findings of the present study concluded that there was a significant association between smokeless tobacco use and obstetrical problems, neonatal problems, oral problems and reproductive health problems.