The study investigated the relationship connecting capital structure and profitability of two listed firms on the Ghana Stock Exchange (GSE) from the year 2010 to 2014. With regards to the firm’s capital structure, the study employed short-term debt to total capital, long-term debt to total capital and total debt to total capital in comparison with return on assets (ROA), return on equity (ROE) and net profit margin (NPM). The mixed method was used to capture both qualitative and quantitative data. The study employed both primary and secondary data and the data was analyzed using multiple regressions. The outcome from the review demonstrates that increments in short term debts and long term obligation influences the execution of the oil marketing companies. The suggestion is that managers ought to ensure that they recognize and keep up the ideal capital structure level to augment the organization's profit base.