A descriptive survey was conducted to assess knowledge regarding post-menopausal ostioporosis among perimenopausal women at selected area of Byahatti PHC, Dharwad dist, Karnataka. Totally 30 perimenopausal women were selected by probability simple random sampling technique. The knowledge was assessed by using structured knowledge Questionnaire. The study results reveal that, majority of subjects 21 (70%) had an average knowledge and remaining 09(30%) had poor knowledge regarding post-menopausal osteoporosis. There was no association found between knowledge scores and their selected demographic variables. The study findings concluded that Overall knowledge scores regarding postmenopausal osteoporosis among perimenopausal women was average and there is a need of health educational programmes to improve their knowledge and take necessary steps to prevent and adequately manage post-menopausal osteoporosis.