Study Objective: To determine and identify the health issues and higher incidences in people of residents or residing in industrial area of Uppal, Hyderabad, Telangana State of India. Study Design: The study population living near or in the industrial area includes Thimmapur, Mallapur, Nacharam, Uppal and other villages of Uppal Industrial residents nearby the industries. For comparison, Non industrial areas of Jagitial district villages (Atmanagar, Jaggasagar, Atmakur, Ibrahimpatnam, Kathalapur etc., ) not exposed to industrial chemicals were selected as control group. A door to door survey was conducted in each village to collect epidemiological data. Results: In this present study gastro, respiratory disorders, hypertension, diabetics and their incidence rates was more predominant than in controls and found to be significance statistically. Other health issues includes neuro disorders and generalised weakness also showed significance when compared with controls group. Conclusions: The results indicated that direct or indirect exposure to various environmental factors including chemicals increasing various health disorders in residents of industrial areas.