The study revolves around meaning relations as anchored on the use of personal pronouns as reference elements in Mende. The relationship between a reference and its referent – the item it presupposes- with respect to personal pronoun antecedent agreement requires semantic explanations regarding certain characteristics owned by the referent or antecedent. It is expected that personal pronouns and their antecedent must agree in the features: gender, person, case and number for want of clarity of meaning, cohesion, and precision of grammar. These features form the characteristics of nouns and pronouns alike. This strict matching order as dictated by semantics, does not obtain in the Mende language of Sierra Leone. This article looks at the semantic relationship between a personal pronoun and its antecedent in the Mende language of Sierra Leone. A purposive sampling technique was used to identify a corpus of the grammar of the language from which reference elements were drawn. The study was largely qualitative, thus describing the meaning relations between personal pronouns and their referents. The findings reveal useful information on the nature of the variety of grammatical elements that occur for case pronouns for the purpose of teaching and learning and for inclusion in the body of literature on the grammar of the language. Furthermore, it is evident that the personal pronouns in Mende do not cohere with the semantic features that are essential to interpreting the relationship between the referent and its referent. Therefore teachers and learners need to be aware of the nuances of personal pronouns in terms of their structure and function in the Mende language.