The aim of this study was to identify and classify the hematological parameters among patients with sickle cell gene who frequently visit El-Obied teaching hospital for medical care. The study was conducted in Ei-obied Town. Agreement was taken from Fourty four (44) patients admitted in alobied hospital to be a part of the study. Blood samples were collected and analyzed for CBC and HB electrophoresis by full analyzer Sysmex and electrophoresis tank. Sickling test was carried for determination of positive or negative (S- gene). The analysis showed mean values of CBC as follows HB (7.3), PCV (24.7), MCV (81.1), MCH (24.2) and MCHC (29.7), TWBCs (17.2), RBCs (3.1), PLT count (327) and RDW (64.1) in SCA patients. In the SCT patients, the analysis showed mean values as HB (11.6), PCV (37.4), MCV (83.4), MCH (25.9) and MCHC (31.1), TWBCs (7.3), RBCs (4.5), PLT (224.8) and RDW (44.1). Electrophoresis results showed frequency of SCT as (45.5%) and SCA as (27.3%). The sickling test was found to be positive for (54.5%) and negative for (45.5%) of the study group.