The purpose of this study is to investigate into factors accounting for the effective implementation of reverse logistics (RL) in Ghana. The study further tries to determine the level of effective implementation of reverse logistics program in selected organizations and assesses the impact of environmental legislation, availability of infrastructure, economic implication and the level of stakeholder awareness on the effective implementation of reverse logistics program. The study reveals that the level of effective implementation of RL in Ghana was moderate. It was also reveals that, environmental legislation, availability of infrastructure has a significantly positive impact on effective implementation of reverse logistics, while economic implication and level of stakeholder awareness have a significantly negative impact on the effective implementation of reverse logistics program. It is recommended that firms should automate their reverse logistics program in order to reduce cost in the long run. It is also recommended that the environmental Protection Agency (EPA) must strictly enforce RL laws to protect our environment. Finally, it is recommended that RL infrastructure should be provided or subsidized by government in order to increase the adoption and effective implementation of the program.