Candidiasis is an opportunistic infection seen in debilitated and immunocompromised patients. It has been well documented that Candida biofilms once formed, exhibit high resistance to antimycotic drugs. Additionally, high doses of these drugs over a prolonged period of time can induce serious side-effects. Hence, the present study was designed to explore a novel approach to control colonization by these yeasts. C.albicans biofilms were exposed to the antimycotic drug, clotrimazole alone and in combination with the flavanoid, quercitin. Additional tests were performed to check the antimicrobial activity of quercitin alone. The reduction in biofilm formation was verified by the viable count technique. Exopolysaccharide formation, indicative of the amount of biofilm formed, was determined by the Anthrone method. Biofilms formed on glass slides were observed by Allison and Sutherland staining. Minimum inhibitory concentration of quercetin and clotrimazole was determined by the broth macrodilution method and was found to be 50 mg/ml and 15 ug/ml respectively. Both antimicrobial compounds when used in combination caused reduction in the viable count and exopolysaccharide formation by Candida. These reductions were more than those induced by clotrimazole and quercetin separately. Thus quercitin, a nutraceutical, could represent an important adjunct to conventional antifungal therapy, employing clotrimazole.