This study examined the study on first year students in Rewa Medical College in psychosocial adjustments, general self-efficacy and Psychological distress. A cross-sectional study was designed and data was collected from 50 first year medical students of a government medical college in Rewa (M.P.). According to GHQ-12, 39.7% (95% CI 29.6-50.7) students had psychological distress; it was slightly higher in male students (33.3%) than their female counterparts (30.0%). The prevalence of psychological distress among first year medical students was high. The causes of psychological distress among medical students should be recognized and strategies should be designed to address those issues.