Background and study Aims: Ulcerative colitis (UC) is a lifelong intestinal inflammatory condition of unknown a etiology. Faecal calprotectin has been proposed as a non-invasive surrogate marker of intestinal inflammation in UC. This study was designed to evaluate the fecal calprotectin as a marker for diagnosis of UC and its remission and exacerbation. Patients and Methods: 60 patients were selected. 40 patients of them had ulcerative colitis (Group I). Group I was evaluated during active UC (GIa), and after remission (G1b). Group II included 20 patients age and sex matched without ulcerative colitis as control.