This report provides multi-dimensional impact of the fourth industrial revolution (industrial revolution 4.0) that has been rapidly changing labor market structure. This will put great pressure on the labor market. Developing countries like Vietnam will face surplus labor and rising unemployment rates; opportunities and challenges for businesses when trade agreements are signed. Approaching the opportunities of the Comprehensive Partnership and Transpacific Progressive Partnership (CPTPP), the rational investment of enterprises for managerial personnel training is needed, because the integration requires managers to have a strategic vision. New solutions to improve the quality of human resources should be in place to take advantage of CP-TPP opportunities by Vietnamese enterprises.