Faidherbia albida belong to the family Mimosaceae. Traditionally, the plant is used in the treatment of diarrhea skin diseases and asthma. The phytochemical studies were carried out and revealed the presence of flavonoids, alkaloids, saponins, Tannin, Phenols, Triterpenes, Cardiac glycoside and Sterols in the Pod extract. While alkaloids, tannins, saponins, sterols, Phenols, Triterpenes and cardiac glycoside in the bark extract. The antibacterial activity was investigated against two Gram positive and two Gram negative bacteria: Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphyococcus aureus. The bark methanolic extract showed the highest antibacterial activity against the test organisms, while the Pod methanolic extract reflected high activity against Bacillus subtilis and moderate activity against the other organisms.