Aim: This study aimed to assess the effectiveness of information brochure on improving the knowledge and practices of caregivers regarding home management of side effects of chemotherapy in selected hospitals from Lucknow, Uttar Pradesh and to find out various factors associated with it. Materials & Methods: A quantitative research approach with Pre-experimental one group pretest and posttest design and Non-probability convenience sampling technique was used to select 60 caregivers in selected hospitals from Uttar Pradesh. A self-structured knowledge questionnaire and practice checklist was used for assessing the knowledge and practice among the subjects. SPSS version 25 was used for data analysis. Results: There was a significant difference between the pre and post intervention level of knowledge (t = 16.1, p= 0.0001) and practice (t = 12.6, p= 0.0001) regarding home management of side effects of chemotherapy among caregivers. There was an association between caregivers knowledge score with their demographic variable educational status (x² = 21.5, p=0.006). There was an association between caregivers practice score with their demographic variables like education (x² = 20.8, p=0.008), occupation (x² = 15.1, p=0.05) and previous information about chemotherapy (x² = 9.1, p=0.01). Conclusion: Information brochure was effective to enhance the knowledge and practice of Caregivers regarding home management of side effects of chemotherapy. A qualitative approach can be used to explore comprehensive findings in future studies.